Prof. Amjad Husain
Professor of Life Sciences
Post doctorate: Harvard University
Short Management Program: Harvard Business School
Ph.D, ICGEB, Delhi. MS, IIT, Roorkee
He spent a few years in Boston, United States, completing his postdoctoral training at Harvard Medical School, and an executive management program at Harvard Business School. Amjad holds a PhD in Biotechnology from ICGEB, New Delhi through ICGEB graduate program with a full scholarship from govt of India, and masters degree in Biotechnology from the Indian Institute of Technology (IIT) Roorkee,
At Harvard, he worked in the area of Bioengineering and Tumor angiogenesis, where he studied VEGF mediated tumor angiogenesis while working with a well known scientist Prof. Harold F. Dvorak. Amjad’s work on VEGF mediated angiogenesis has led to a collaboration with companies like Imclone Inc and Eli Lily in USA for drug discovery and clinical applications of novel VEGFR inhibitors. Later, he was involved in designing and building up a high throughput drug screening platform, which got commercialized through a start-up company in Boston, and is being used by various pharmaceutical companies including Amgen. He also studied the role of biomechanical factors in tumorigenesis and age related macular degenration (AMD).
Amjad has published a number of papers in well-known international journals in the areas of HIV pathogenesis, Oncology, and Bioengineering. He has also presented his work in many international scientific meetings as Speaker including Keystone Symposium in Canada, Gordon conference in USA, and HHMI proteomics conference in Mexico. He was an active member of the Harvard innovation lab, and a selected candidate for the Harvard Healthcare Commercialization program in 2014, where he was mentored by Nobel laureates from the field and founders of Biotech companies around Boston Cambridge area. Amjad is passionate for teaching and interested in technology development.
1. Yamicia D. Connor, Sarah Tekleab, Shyama Nanda, Cherelle Walls , Amjad Husain, Thomas Reiberger, Or Gadish, Venkata Sabbisetti, Shelley Kaushik, Ashish Kulkarni , Harold Dvorak , Bruce Zetter, Rakesh Jain, Elazer Edelman, Shiladitya Sengupta. Physical nanoscale conduits-mediated communication between tumor cells and endothelium enables a metastatic hijack. Nature communications, Dec 2015. (Impact factor 11.5).
2. Sari Tojkander, Gergana G, Amjad Husain, Ramaswamy Krishnan, Pekka Lappalainen. Generation of contractile actomyosin bundles depends on mechanosensitive actin filament assembly and disassembly. eLife, Dec 2015 (Impact factor 9.5).
3. Mark Duquette, Peter Sadow, Amjad Husain*, Andrew Fischer, Chen Song, Elena Rizaldos, Mike Makrogiorgos, Junichi Kurebayashi, Vania Nose, Paul Hummelen, Roderick Bronson, Dora Santagata, Pier Paolo Pandolfi, Carmelo Nucera. First pre-clinical trial of vemurafenib in BRAFV600E–papillary thyroid cancer reveals metastasis associated MCL1 and P16/CDKN2A copy number alterations and drug resistance. Oncotarget, Aug 2015 (Impact factor 7.0). *Co- first author.
4. Amjad Husain, Nina Hu, Peter Sadow, Carmelo Nucera. Expression of angiogenic switch, cachexia and inflammation factors at the crossroad in undifferentiated thyroid carcinoma with BRAFV600E. Cancer Letters, July 2015 (Impact factor 7.5).
5. Sadow PM, Priolo C, Nanni S, Karreth FA, Duquette M, Martinelli R, Husain A, Clohessy J, Kutzner H, Mentzel T, Carman CV, Farsetti A, Henske EP, Palescandolo E, Macconaill LE, Chung S, Fadda G, Lombardi CP, De Angelis AM, Durante O, Parker JA, Pontecorvi A, Dvorak HF, Fletcher C, Pandolfi PP, Lawler J, Nucera C, "BRAFV600E is a novel driver of multifocal infiltrating myopericytoma development" Journal of National Cancer Institute (JNCI) 2014 (Impact factor 15.0).
6. Janice A. Nagy, Amjad Husain, Shou-Ching Jaminet, and Harold F. Dvorak. The tumor vasculature: structure and function. MR and CT Perfusion Imaging, 2013.
7. Shaik S, Nucera C, Inuzuka H, Gao D, Garnaas M, Frechette G, Harris L, Wan L, Fukushima H, Husain A, Nose V, Fadda G, Sadow PM, Goessling W, North T, Lawler J, Wei W. SCFβ- TRCP suppresses angiogenesis and thyroid cancer cell migration by promoting ubiquitination and destruction of VEGF-Receptor-2, Journal of Experimental Medicine 2012 (Impact factor 15.3).
8. Rupam Sahoo, Amjad Husain* and Elaine A. Elion. MAP Kinase in Yeast. Handbook of Cell Signaling 2009. Oxford Academic Press. (*Co first author).
9. Amjad Hussain, Mohammad Khalid, Clement Wesley, Ashutosh Chaudhry and Shahid Jameel. The HIV-I Vpu protein interacts with CD74 and modulates major histocompatibility complex II presentation. Journal of Virology. 2008 (Impact factor 6.0).
10. Amjad Hussain, Suman Ranjan Das, Charu Tanwar and Shahid Jameel. Oligomerization of the human immunodeficiency virus type 1 (HIV-1) Vpu protein – a genetic, biochemical and biophysical analysis. Virology Journal. 2007 (Impact factor 3.2).
11. Kartik Padhan, Charu Tanvar, Amjad Hussain, P.Y. Hui, M.Y. Lee, C.Y. Cheung, J.S.M. Peiris and Shahid Jameel. The SARS coronavirus Orf3a protein interacts with caveolin. Journal of General Virol. 2007 (Impact factor 4.0).
12. Ashutosh Chaudhry, Suman Ranjan Das, Amjad Hussain, Satyajit Mayor, Anna George, Vineeta Bal, Shahid Jameel and Satyajit Rath. The Nef protein of HIV-1 induces loss of cell surface costimulatory molecules CD80 and CD86 in APCs. Journal of Immunology, 2005 (Impact factor 7.0).
13. Amjad Husain, Arogya Khadka, Harold F. Dvorak, Magali S. Geniez, and Ramaswamy Krishnan. The pro-angiogenic potential of VEGF is enhanced by matrix rigidity. AJP Cell. (Submitted)
14. Amjad Husain, Janice A. Nagy and Harold F. Dvorak. VEGF-C induces lymphangiomas by activation of VEGFR2 and VEGFR3 through Akt/mTOR pathways. Cancer Res (Submitted).
Review Articles/Book Chapters:
15. Shikha Taneja, Amjad Husain. Protein folding and tumour Angiogenesis, do we know enough MOJ Proteomics & Bioinformatics. 2015.
16. Suman ranjan Das, Amjad Hussain, Shahid Jameel. Role of accessory proteins in HIV pathogenesis. Sir Dorabji Tata Conf on AIDS. IISc Bangalore, 2005.
Manuscripts under preparation:
16. Amjad Husain, Janice A. Nagy, Laura E. Benjamin and Harold F. Dvorak. Inhibition of VEGF- A, VEGF-C, and VEGF-E induced blood vasculature, using VEGFR2 and VEGFR3 as therapeutic targets.
17. Allen Ehrlicher, Quynh Dang, Amjad Husain, Kavitha Rajendran, Jeffrey J. Fredberg, and Ramaswamy Krishnan. High-throughput measurements of cell-generated contractile forces in endothelial cells using silicon deformable substrate.
Published Abstracts in conferences (Only key abstracts are listed):
18. Sukhmani Padda, Yesim Gokmen, Sunil Badve, Kabya Basu, Ansu Kumar, Amjad Husain, Shireen Vali, Taher Abbasi, Heather Wakelee. Designing Novel Therapies for Clinical Translation through Predictive Simulation for Thymoma. ITMIG 2016, San Fransisco, USA.
19. Amjad Husain, Sonia Rosner, Quynh Dang, Magali Saint-Geniez and Ramaswamy Krishnan. Role of contractile forces in Retinal pigmented epithelial dysfunction. Vascular biology Annual retreat, BIDMC, Harvard Medical School, Boston, 2014.
20. Amjad Husain, Janice A. Nagy and Harold F. Dvorak. VEGF-A and VEGF-C induce heterogeneous vasculature in mouse ear model. Vascular biology Annual retreat, BIDMC, Harvard Medical School, Boston, 2012.
21. Amjad Husain, Janice A. Nagy and Harold F. Dvorak. VEGF-A and VEGF-C induce differential angiogenesis and lymphangiogenesis in immunodeficient mice by differential activation of Akt-mTOR pathways. CVBR Annual retreat, Harvard Medical School, 2012.
22. Yamicia D. Connor, Sarah Tekleab, Mathew F, Taylor Lloyd, Amjad Husain, Michael S. Oh, Divya Bharat, Shyam Nathan, Cherelle R. Walls, Nicki Watson, Shiladitya Sengupta. Intercellular transfer between metastatic cells and the endothelium Mediated by tunneling nanotubes. American Association of Cancer Research AACR, USA 2012.
23. Amjad Husain, Janice A. Nagy and Harold F. Dvorak. VEGF-A and VEGF-C mediated endothelial cell proliferation is Akt dependent and differentially regulated in lymph and blood endothelial cells. Vascular biology retreat, Harvard Medical School, Boston, 2011.
24. Amjad Husain, Laura E Benjamin, Janice A. Nagy, and Harold F. Dvorak. Differential signaling of VEGF-A and VEGF-C in lymphatic vs. blood endothelial cells: Role of Akt and downstream targets. Gordon Conference University of Maine, 2010.
25. Amjad Husain, Mark Scheff, Elaine A. Elion. Defining pathways required for MAPK-induced polarized growth in Yeast. Biological Chemistry and Molecular Pharmacology annual meeting, Harvard Medical School Boston, 2009.
26. Amjad Husain, Mohammad Khalid, Clement Wessley, Shahid Jameel. HIV-1 Vpu down- regulates MHCII in CD74 dependent manner. Keystone Symposium Banff Canada 2008.
27. Amjad Husain, Suman Ranjan Das, Charu Tanvar, Shahid Jameel. Oligomerization of the human immunodeficiency virus type 1 (HIV-1) Vpu protein and its sub-cellular co-localization. HHMI Proteomics workshop, UNAM, Mexico 2005.
28. Amjad Husain, Suman Ranjan Das, Charu Tanvar, Shahid Jameel. Oligomerization and colocalization of HIV-Vpu protein in ER-Golgi regions. AICOM-JNCASR joint conference on HIV epidemics, New Delhi India 2006.
29. Amjad Husain, Suman Ranjan Das, Shahid Jameel. HIV-1 Vpu interacts with CD74 through its cytoplasmic domain in yeast two hybrid system. Sir Dorabji TATA Symposium IISc Bangalore 2006.